Recombinant DNA Technology
Under which of the following conditions would population gene frequencies remain the same?

Small population size
Active migration between groups
Random mating
Selection for homozygotes

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Recombinant DNA Technology
Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

PCR-amplified variable numbers of tandem repeats (VNTRs)
copies of the gene with an altered sequence so that a restriction site is inserted
short sequences that will hybridize only to a specific base sequence
mutagenized copies of a gene

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