Microorganisms and Disease
The nature of the poliovirus gives for oral vaccination (satin vaccine) as part of the eradication programme is

heat killed virus
formalin-inactivated viruses
small dosage of wild-type live viruses
live attenuated strains of all three immunological types

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Microorganisms and Disease
The influenza vaccine is administered each year because

the vaccine is sufficiently toxic to make it necessary to administer only a small amount at any one time
mutations in the viral hemagglutinin may allow the virus to evade the immune response elicited by previous vaccines
it is a polysaccharide vaccine that does not confer long-term protection
None of these

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Microorganisms and Disease
A major difference between EHEC and EPEC is

EPEC rearranges host cell actin and EHEC does not
EPEC passes through the placenta to infect the fetus and EHEC does not
EHEC secretes a Shiga-like toxin and EPEC does not
EHEC possesses a type III secretion system and EPEC does not

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of guanylate cyclase that stimulates production of cGMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
ADP ribosylation of adenylate cyclase that stops production of cAMP

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

forms cAMP that leads to fluid accumulation
lysis macrophages with the release of cytokines
binds host cell receptors found on heart cells
cause ADP ribosylation of a factor involved in protein synthesis

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