Microorganisms and Disease
A major difference between EHEC and EPEC is

EPEC passes through the placenta to infect the fetus and EHEC does not
EHEC possesses a type III secretion system and EPEC does not
EHEC secretes a Shiga-like toxin and EPEC does not
EPEC rearranges host cell actin and EHEC does not

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

lysis macrophages with the release of cytokines
cause ADP ribosylation of a factor involved in protein synthesis
binds host cell receptors found on heart cells
forms cAMP that leads to fluid accumulation

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of guanylate cyclase that stimulates production of cGMP
ADP ribosylation of adenylate cyclase that stops production of cAMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP

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Microorganisms and Disease
Which of the following is common in the disease caused by Coryne-bacterium diphtheriae and Bacillus anthracis?

Diphtheria toxin and edema toxin are ADP ribosylating toxins
Both organisms are gram-positive spore formers
The most serious disease symptoms are the direct result of toxin action
Both organisms cause skin and respiratory tract infections

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