Microorganisms and Disease
What is common in catheters and ventilators?

They are used primarily in neonatal intensive care units
Bacteria responsible for associated infections are usually susceptible to antibiotics
They bypass important defenses of the body
They predispose patients to viral rather than bacterial infections

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Microorganisms and Disease
A major difference between EHEC and EPEC is

EPEC passes through the placenta to infect the fetus and EHEC does not
EPEC rearranges host cell actin and EHEC does not
EHEC secretes a Shiga-like toxin and EPEC does not
EHEC possesses a type III secretion system and EPEC does not

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Microorganisms and Disease
Type III secretion systems are used to inject "effector" proteins directly into a host cell. Salmonella uses a type III secretion system to help the pathogen to

survive the acid pH of the stomach
survive within macrophages
secrete LT (heat labile toxin) and ST (heat stable toxin) into the lumen of the intestine
activate T cells to proliferate and secrete cytokines

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Microorganisms and Disease
Which of the following is common in the disease caused by Coryne-bacterium diphtheriae and Bacillus anthracis?

The most serious disease symptoms are the direct result of toxin action
Both organisms are gram-positive spore formers
Diphtheria toxin and edema toxin are ADP ribosylating toxins
Both organisms cause skin and respiratory tract infections

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
ADP ribosylation of adenylate cyclase that stops production of cAMP
ADP ribosylation of guanylate cyclase that stimulates production of cGMP
cleavage of rRNA that results in disruption of ribosome function

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