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Disease Associated with Immune System

Disease Associated with Immune System
Retinoblastoma is due to a mutation in a

viral gene
cyclin
kinase
tumor supressor

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Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2
nude mouse
recombinant mouse for CD3
knock-out mouse for a thymus

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Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages
infections following dental work due to bacteria entering the bloodstream
bacterial infections
mucosal pathogens

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Disease Associated with Immune System
A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Ser or Thr
Leu or Ileu
Tyr or Phe
His or Pro

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Disease Associated with Immune System
Specific translocations are associated with

pancreatic cancer
colon cancer
breast cancer
some leukemias

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Disease Associated with Immune System
Combined cellular and humoral immune deficiencies result from lack of all of the following except

HIV infection of CD4+ T cells
a thymus
transporter of antigen peptides (TAP)
class II MHC

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