Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

limited life span of more mature hematopoietic cells
inserting a gene so that it will function properly
transducing genetic material into stem cells
GVHD caused by mature T cells in the transplanted cells

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses
macrophage intracellular killing of bacteria
infected cell processing of virus peptides
dendritic cell activation to become a mature APC

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

come from one of the child's parents
be irradiated to eliminate GVHD
contain mature T cells that can begin making immune responses immediately
come from a donor that shares some MHC alleles with the recipient

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