Microorganisms and Disease
Plastic implants can pose a serious nosocomial infection problem because

infected implants usually have to be surgically removed
All of these
phagocytes have trouble moving on the plastic surface
phagocytes have trouble engulfing bacteria embedded in a biofilm

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

cause ADP ribosylation of a factor involved in protein synthesis
forms cAMP that leads to fluid accumulation
lysis macrophages with the release of cytokines
binds host cell receptors found on heart cells

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