Microorganisms and Disease
Both Mycobacterium tuberculosis and Streptococcus pneumoniae

are acquired by inhalation
have polysaccharide capsules
stay in the lung and rarely, if ever, enter the bloodstream
have cell walls that contain a high content of mycolic acids

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

cause ADP ribosylation of a factor involved in protein synthesis
binds host cell receptors found on heart cells
forms cAMP that leads to fluid accumulation
lysis macrophages with the release of cytokines

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Microorganisms and Disease
What is common in catheters and ventilators?

They bypass important defenses of the body
They are used primarily in neonatal intensive care units
Bacteria responsible for associated infections are usually susceptible to antibiotics
They predispose patients to viral rather than bacterial infections

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