Enzymes
Which of the common features are shared between serine and aspartate proteases?

All of these
Both require water to complete the catalytic cycle
Both use a base to activate the nucleophile
Both show specificity for certain amino acid sequences

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

retard the reduction of pyruvic acid to acetyl Co A and CO2
decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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Enzymes
Which of the following statements about enzymes or their function is true?

All of these
Enzymes do not alter the overall change in free energy for a reaction
Enzymes speed up reactions by lowering activation energy
Enzymes are proteins whose three-dimensional form is key to their function

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both show specificity for certain amino acid sequences
Both forms an acyl-enzyme intermediate
Both require water to complete the catalytic cycle
Both use nucleophilic attack to hydrolyze the peptide bond

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

size, shape, and charge of the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket
absence of water in the active site

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