Antigen
Very low doses of antigen may induce

low zone tolerance
low zone immunity
hypersensitivity
immunological ignorance

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
antigen is hidden from the immune system in macrophages
innate immune effectors are eliminating antigen
innate immunity blocks the activation of adaptive immune effector cells

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Antigen
For specific antigen recognition by T cells,

antigen is bound by a T cell membrane antibody
denaturation of antigen does not reduce epitope recognition
MHC molecules are not required
antigen exposure during T cell maturation is required

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