Antigen
Very low doses of antigen may induce

low zone tolerance
low zone immunity
immunological ignorance
hypersensitivity

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

antigen is hidden from the immune system in macrophages
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
innate immunity blocks the activation of adaptive immune effector cells
innate immune effectors are eliminating antigen

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Antigen
CD antigens

function as receptors for cytokine and CAMs
allow leukocytes to recognize antigen
are each expressed on only one cell type
are expressed on immune cells to mark them for separation

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