Antigen
Antigen, when injected in the body activates its specific lymphocytes in the

draining lymph nodes
blood circulation
MALT (mucosa associated
spleen lymphoid tissue

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immune effectors are eliminating antigen
antigen is hidden from the immune system in macrophages
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
innate immunity blocks the activation of adaptive immune effector cells

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Antigen
For specific antigen recognition by T cells,

antigen exposure during T cell maturation is required
MHC molecules are not required
denaturation of antigen does not reduce epitope recognition
antigen is bound by a T cell membrane antibody

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