Antigen
A virus vaccine that can activate cytotoxic T cells must contain

live virus
a high dose of virus particles
virus peptides
an adjuvant to stimulate T cell division

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
antigen is hidden from the immune system in macrophages
innate immunity blocks the activation of adaptive immune effector cells
innate immune effectors are eliminating antigen

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Antigen
For specific antigen recognition by T cells,

antigen is bound by a T cell membrane antibody
MHC molecules are not required
denaturation of antigen does not reduce epitope recognition
antigen exposure during T cell maturation is required

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