Cell Signalling and Transduction
The signaling molecules called steroid hormones

never enter the blood of humans
are hydrophilic and so cannot penetrate the plasma membrane
bind to cell surface receptors to trigger chemical cascades
are made in one location of the body but have their effects some distance away

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Cell Signalling and Transduction
A signal cascade induced by adrenaline or thyroxine

involves the activation of a G protein
All of these
must begin with receipt of the signal molecule by a surface receptor
results in the activation of a sequence of enzymes needed for the cell effect

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Cell Signalling and Transduction
Why is it that inhaling nitric oxide reduces blood pressure only in the lung tissue and not elsewhere in the body*?

Because other body tissues use a different signaling molecule
Because nitric oxide cannot cross cell membranes and enter the blood
Because nitric oxide breaks down quickly and thus cannot travel far
None of these

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