Microorganisms and Disease
Lactoferrin helps to protect against pathogens by

lowering the pH
blocking sebum production
facilitating the growth of normal flora
sequestering Iron

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of adenylate cyclase that stops production of cAMP
ADP ribosylation of guanylate cyclase that stimulates production of cGMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP

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Microorganisms and Disease
Plastic implants can pose a serious nosocomial infection problem because

All of these
phagocytes have trouble moving on the plastic surface
infected implants usually have to be surgically removed
phagocytes have trouble engulfing bacteria embedded in a biofilm

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Microorganisms and Disease
Type III secretion systems are used to inject "effector" proteins directly into a host cell. Salmonella uses a type III secretion system to help the pathogen to

survive within macrophages
activate T cells to proliferate and secrete cytokines
secrete LT (heat labile toxin) and ST (heat stable toxin) into the lumen of the intestine
survive the acid pH of the stomach

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Microorganisms and Disease
A major difference between EHEC and EPEC is

EHEC secretes a Shiga-like toxin and EPEC does not
EHEC possesses a type III secretion system and EPEC does not
EPEC rearranges host cell actin and EHEC does not
EPEC passes through the placenta to infect the fetus and EHEC does not

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