Recombinant DNA Technology
Which of the following is not true of small inbreeding populations?

There is an increased incidence of recessive diseases
They tend to loose genetic diversity
Alleles may become fixed
Mutation is increased

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Recombinant DNA Technology
Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

copies of the gene with an altered sequence so that a restriction site is inserted
mutagenized copies of a gene
short sequences that will hybridize only to a specific base sequence
PCR-amplified variable numbers of tandem repeats (VNTRs)

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