DNA Structure and Replication
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

It has low affinity for the correct dNTP's
It lacks a proofreading exonuclease
AZT (zidovudine) is too expensive to be taken in effective doses
The RNase H domain of p66 causes error prone synthesis

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DNA Structure and Replication
In DNA, nucleotides are covalently joined together by

3', 5' phosphodiester bonds to form a repetitive sugar-phosphate chain
3', 4' phosphodiester bonds to form a repetitive sugar-phosphate chain
2', 3' phosphodiester bonds to form a repetitive sugar-phosphate chain
2', 5' phosphodiester bonds to form a repetitive sugar-phosphate chain

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