Water, pH and Macromolecules
Polyprotic acids such as H3PO4, can act as acid-base buffers

at pH values around any of their pKa's
only in combination with polyprotic bases
at pH values around neutrality
if their concentration is kept low

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Water, pH and Macromolecules
Hydrogen bonds and hydrophilic interactions are types of

weak chemical bonds that link together separate molecules
strong chemical bonds that hold together the atoms within a molecule
weak chemical bonds that hold together the atoms within a molecule
strong chemical bonds that link together separate molecules

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Water, pH and Macromolecules
The main difference between an acid and a base is that

acids donate hydrogen ions in water while bases accept hydrogen ions
bases are polar molecules and acids are not
bases donate hydrogen ions in water while acids accept hydrogen ions
acids are polar molecules and bases are not

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