Water, pH and Macromolecules
Polyprotic acids such as H3PO4, can act as acid-base buffers

only in combination with polyprotic bases
if their concentration is kept low
at pH values around any of their pKa's
at pH values around neutrality

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Water, pH and Macromolecules
The main difference between an acid and a base is that

acids are polar molecules and bases are not
bases are polar molecules and acids are not
acids donate hydrogen ions in water while bases accept hydrogen ions
bases donate hydrogen ions in water while acids accept hydrogen ions

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