Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2
nude mouse
recombinant mouse for CD3
knock-out mouse for a thymus

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized
the virus particles with altered (mutant) proteases arise
the drugs are rapidly degraded
the drugs interfere with normal digestion

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of B cells to provide co-stimulation for Th2 activation
failure of Th2 cells to provide co-stimulation for B cell isotype switching

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria
CTL killing of viruses
dendritic cell activation to become a mature APC
infected cell processing of virus peptides

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