Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus
nude mouse
recombinant mouse for CD3
knock-out mouse for RAG-1 and RAG-2

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC
infected cell processing of virus peptides
CTL killing of viruses
macrophage intracellular killing of bacteria

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