DNA Sequencing, Mutation and Repair
The whole-genome shotgun sequencing approach depends primarily on

sequencing the bacterial chromosome while it is still intact
methodical sequencing a few large cloned fragments of DNA
All of these
rapidly sequencing thousands of small randomly cloned fragments

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DNA Sequencing, Mutation and Repair
A mutagen is defined as

a molecule which stabilizes DNA thus prevents mutations from occurring
a chemical or physical agent that induces mutations
an inhibitor of gene modification
an enzyme that repairs mutations

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