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Monoclonal Antibodies

Monoclonal Antibodies
Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

IgA
IgE
IgG
Ig MAbs

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

Hybridization with a suitable lymphoid tumor cell
All of these
Transfection with tumor derived DNA
Transformation following infection by Epstein-Barr virus (EB V)

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Monoclonal Antibodies
The cross linkage of antigens by antibodies is known as

complement fixation
all of these
agglutination
a cross reaction

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Monoclonal Antibodies
Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

absence of human immune response against murine proteins (HAMA) response
poor recognition of immunoglobulin, Ig constant regions
All of these
presence of HAMA response

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Monoclonal Antibodies
In human B cells and T cells are matured in the

lymph nodes and spleen respectively
bone marrow and thymus respectively
none of these
bursa and thymus respectively

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Monoclonal Antibodies
Helper T cells assist in the functions of

None of these
certain B cells
certain B cells and other T cells
certain T cells

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