Chemical Reaction Engineering
Enzymes are destroyed, when the

Temperature is very high
Reactant's concentration is very low
Reaction rate is independent of the reactant's concentration
Reactant's concentration is very high

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Chemical Reaction Engineering
A catalyst loses its activity due to

All of these
Loss in surface area of the active component
Covering of the catalytic active sites by a foregin substance
Agglomeration of metal particles caused by thermal sintering of the solid surface

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