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Antimicrobial Chemotherapeutic Agents

Antimicrobial Chemotherapeutic Agents
Amphotericin B and polymyxin interfere with

cell membrane function
protein synthesis
cell wall synthesis
DNA function

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Antimicrobial Chemotherapeutic Agents
The antibiotics not having good activity against Enterobacteriaceae is

ciprofloxacin
clindamycin
cefoxitin
trimethoprim-sulphamethoxazole

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Antimicrobial Chemotherapeutic Agents
Who developed the concept of specific toxicity?

Ehrlich
Watson
Fleming
Pasteur

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Antimicrobial Chemotherapeutic Agents
Polyene antibiotics are

small ring structures
β-lactam - thiazolidine ring
any of these
large ring structures

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Antimicrobial Chemotherapeutic Agents
Both penicillin and fluoroquinolones

must be transported into the cytoplasm in order to act
inhibit the cross-linking of peptidoglycan
are inactivated by β-lactamase
bind to and inactivate a bacterial protein

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Antimicrobial Chemotherapeutic Agents
Vancomycin inhibits peptidoglycan synthesis by binding

D-alanyl - D-alanine synthetase
amidase
alanine racemase
D-alanyl - D-alanine

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